Selective excitation enables encoding and measurement of multiple diffusion parameters in a single experiment

MacKinnon, Neil; Alinaghian, Mehrdad; Silva, Pedro; Gloge, Thomas; Luy, Burkhard; Jouda, Mazin; Korvink, Jan G.

Band selectivity to address specific resonances in a spectrum enables one to encode individual settings for diffusion experiments. In a single experiment, this could include different gradient strengths (enabling coverage of a larger range of diffusion constants), different diffusion delays, or different gradient directions (enabling anisotropic diffusion measurement). In this report, a selective variant of the bipolar pulsed gradient eddy current delay (BPP-LED) experiment, enabling selective encoding of three resonances, was implemented. As proof of principle, the diffusion encoding gradient amplitude was assigned a range dependent on the selected signal, thereby allowing the extraction of the diffusion coefficient for water and a tripeptide (Met-Ala-Ser) with optimal settings in a single experiment.

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MacKinnon, Neil / Alinaghian, Mehrdad / Silva, Pedro / et al: Selective excitation enables encoding and measurement of multiple diffusion parameters in a single experiment. 2021. Copernicus Publications.

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