Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator

Ellermann, Frowin; Pravdivtsev, Andrey; Hövener, Jan-Bernd

The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (inline-formulapHinline-formula2)-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a inline-formulapHinline-formula2 generator is necessary. Available commercial inline-formulapHinline-formula2 generators are relatively expensive (EUR 10 000–150 000). To facilitate the spread of inline-formulapHinline-formula2-based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR inline-formula<3000) 50-bar liquid-nitrogen-cooled inline-formulapHinline-formula2 generator.

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Ellermann, Frowin / Pravdivtsev, Andrey / Hövener, Jan-Bernd: Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator. 2021. Copernicus Publications.

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Rechteinhaber: Frowin Ellermann et al.

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