Detection of insertion/deletions (indels) of the ATBF1 gene and their effects on growth-related traits in three indigenous goat breeds

Wei, Zhenyu; Wang, Ke; Hui, Yiqing; Yan, Hailong; Zhu, Haijing; Qu, Lei; Pan, Chuanying; Chen, Hong; Lan, Xianyong

The AT motif-binding factor (ATBF1), also known as zinc finger homeobox 3 (ZFXH3), is necessary for activating the POU1F1 gene; thus, the ATBF1 gene greatly affects the grow traits in animals. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Two indels within the ATBF1 gene were found in the Shaanbei white cashmere goat (SWCG; inline-formulan=581), the Guanzhong dairy goat (GZDG; inline-formulan=334) and the Hainan black goat (HNBG; inline-formulan=270) for the first time using 12 pairs of primers. Association analysis revealed that the P1-12-bp indel was consistently correlated with the body height of the three breeds, and individuals with ID (insertion/deletion) and DD (deletion/deletion) genotypes had a higher body weight than the II (insertion/insertion) genotype (inline-formulaP=0.036); the P11-6-bp indel was consistently correlated with chest circumference and hip width of the three breeds. Moreover, these two loci were associated with other several growth-related traits in different breeds. Hence, these findings indicated that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry by implementing marker-assisted selection (MAS).

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Wei, Zhenyu / Wang, Ke / Hui, Yiqing / et al: Detection of insertion/deletions (indels) of the ATBF1 gene and their effects on growth-related traits in three indigenous goat breeds. 2018. Copernicus Publications.

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