Effect of ovariectomy on proximal tibia metaphysis and lumbar vertebral body in common marmoset monkeys

Schlumbohm, Christina; Seidlová-Wuttke, Dana; Fuchs, Eberhard

This study aimed to investigate the effect of estrogen withdrawal on bone tissue in adult female marmoset monkeys. In a 1-year follow-up study we used quantitative computer tomography to measure total bone mineral density (BMD) of the proximal tibia and the second-last lumbar vertebral body (L5/L6) before and 1, 3, 6, and 12 months after ovariectomy. Body mass did not significantly change during the 1-year observation period. However, a significant decline of total BMD after ovariectomy was observed in the proximal tibia but not in L5/L6. In addition, regression analysis showed a significant positive relationship between BMD and body mass in both tibia and L5/L6. The results of our study support the idea that ovariectomized marmoset monkeys may serve as a model to investigate bone loss related to decline of estrogen production.

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Schlumbohm, Christina / Seidlová-Wuttke, Dana / Fuchs, Eberhard: Effect of ovariectomy on proximal tibia metaphysis and lumbar vertebral body in common marmoset monkeys. 2019. Copernicus Publications.

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Rechteinhaber: Christina Schlumbohm et al.

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